Welcome to the Brucella Bioinformatics Portal (BBP)!
This website is dedicated to becoming a bioinformatics resource portal for the Brucella research community to facilitate Brucella reearch.
The focus of BBP is on Brucella genome annotation with literature mining and curation.
Brucella is a Gram-negative, facultative intracellular coccobacillus which causes Brucellosis in humans and animals. The Brucellae are taxonomically placed in the alpha-2 subdivision of the class Proteobacteria. Traditionally there are six species of Brucella based on the preferential host specificity: B. melitensis (goats), B. abortus (cattle), B. suis (swine), B. canis (dogs), B. ovis (sheep) and B. neotomae (desert mice);
two new species B. cetaceae (cetacean) and B. pinnipediae (seal) have recently been described by Cloeckaert et al. [Microbes Infect (2001) 3, 729-738]. The first four species are pathogenic to humans in decreasing order of severity making brucellosis a zoonotic disease. These Brucella species have been identified as priority agents amenable for use in biological warfare and bio-terrorism and listed as NIAID category B priority pathogens. Complete genome sequences of 4 Brucella strains are now available. Brucella genome usually has two circular chromosomes of approximately 2.1 MB and 1.2 MB and has a GC content of approximately 57%. There are approximately 3,200 - 3,400 ORFs in each genome. The DNA sequences among different Brucella spp. share greater than 90% homology. The Brucella taxonomy is available here from the NCBI Taxonomy database and is also overseen by the Brucella Taxonomy Committee. More detailed Brucella background information is available here.
PHIDIAS includes a list of programs for analysis of
Brucella and host-Brucella interactions:
- General Information: General information about Brucella and brucellosis as part of Phinfo. Please click here for advanced topic search of Brucella and brucellosis.
- Brucella GBrowse: Brucella genome browser. This program allows searching, comparison, and visualization of
Brucella genomes and individual DNA/protein/RNA sequences. It is part of PGBrowser and also allows comparison with other genome sequences.
- Gene Query: This program searches
Brucella and host genes. This is part of Phigen that also be used to compare with other pathogen genes.
- Protein Domains in Brucella: This program searches
Brucella -specific protein domains. As an integrated part of Pacodom, this program can also be used to search and compare protein domains of other pathogens
- Brucella as a Hazard: This program focuses on
Brucella-related safety and administrative issues. It is part of HazARD that is also able to compare safety and administrative issues between
Brucella and other pathogens.
- Host-Brucella Interaction Network: this program analyze networks involving the interactions between Brucella and hosts. It is part of Phinet that also targets for many other pathogens.
- Brucella-specific Gene Expression: Phix.
- Interaction between Brucella and Macrophages: MacroPath.
Note: Other BBP programs are listed on the BBP navigation menu on the left.
Other relevant projects developed by He Group:
Publication:
Zuoshuang Xiang, Wenjie Zheng and Yongqun He. BBP: Brucella genome annotation with literature mining and curation. BMC Bioinformatics. 2006 Jul 16;7(1):347. (Highly Accessed). PMID: 16842628.
Listed are the news related to Brucella research and development. Please submit your news to us and we will have it posted here. Thank you.
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